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PF 06260933 dihydrochloride
Axon 2545
- Parent CAS: 1811510-56-1
Purity:
99%
- Soluble in water and DMSO
- MF: C16H13ClN4.2HCl
- MW: 369.68
Description
PF 06260933 dihydrochloride is a potent and selective inhibitor of MAP4K4 (HGK/ZC1). It has pharmacokinetic properties suitable for preclinical in vivo use and supports studies of inflammatory and metabolic kinase signaling.
MAP4K4 regulates stress kinase pathways, inflammatory responses, insulin signaling and tissue injury mechanisms. PF 06260933 dihydrochloride is useful for investigating MAP4K4-dependent signaling in disease-relevant cellular and animal models.
Key Features
- Selective MAP4K4 kinase inhibitor
- Reported IC50: 3.7 nM for MAP4K4
- Suitable mouse pharmacokinetic profile reported for in vivo studies
- Targets inflammatory and metabolic stress signaling pathways
Applications
- MAP4K4 kinase pharmacology
- Inflammation and stress signaling studies
- Metabolic and insulin pathway research
- In vivo kinase inhibitor model studies
More Information
| Parent CAS No. | 1811510-56-1 |
|---|---|
| Chemical Name | 5-(4-chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride |
| extra_info | . |
| SMILES | C1=NC(N)=C(C2=CC=C(Cl)C=C2)C=C1C1=CC=C(N)N=C1.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C16H13ClN4.2ClH/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11;;/h1-9H,(H2,18,20)(H2,19,21);2*1H |
| InChiKey | VRQXEOPUAQLBQI-UHFFFAOYSA-N |
| CID | 118701007 |
| Short Description | MAP4K4 inhibitor |
References
- M. Ammirati et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.
- R.J. Roth Flach et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015 Dec 21;6:8995.
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