PPAR
A second member of the family of nuclear receptors (Nuclear class 1C, Thyroid Hormone Receptor-like) consists of peroxisome proliferator-activated receptors (PPAR, α, β, γ, and δ). They play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. The clinical importance of PPARs originates with fibrates and thiazolidinediones (TZDs), which respectively act on PPAR-α and PPAR-γ. They are used to ameliorate hyperlipidemia and hyperglycemia in subjects with type 2 diabetes mellitus. More recently, proof was found that PPARs also contribute to the regulation of certain physiological activities of the prostacyclin (PGI2) system in cardiovascular tissues[1].
[1] Peroxisome Proliferator-Activated Receptors (PPARS): A Target with a Broad Therapeutic Potential for Human Diseases: An Overview. M.P. Singh, D. Pathak, G.K. Sharma, C.S. Sharma. Pharmacologyonline 2011, 2, 58-89.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3904 | BAY-0069 | Potent covalent PPARγ inverse agonist | €90.00 | |
| 3809 | BAY-4931 | Potent covalent PPARγ inverse agonist | €120.00 | |
| 1950 | CDDO | A potent multifunctional anti-tumor agent. PPAR-γ agonist | €80.00 | |
| 2114 | CP 775146 | Potent and selective PPARα agonist | €85.00 | |
| 2727 | Elafibranor | Dual PPARα/δ agonist | €90.00 | |
| 2686 | FH535 | Dual inhibitor of PPAR and Wnt/β-catenin signaling | €75.00 | |
| 2706 | FH535 sodium salt | Dual inhibitor of PPAR and Wnt/β-catenin signaling | €80.00 | |
| 1628 | GSK 3787 | PPARδ antagonist | €90.00 | |
| 1237 | GW 7647 | PPARα agonist | €95.00 | |
| 2262 | GW 9662 | Selective PPARγ antagonist | €60.00 | |
| 2533 | Hydroxypioglitazone | Active metabolite of Pioglitazone (M-IV), a PPARγ agonist | €180.00 | |
| 2019 | INT131 | Selective PPARγ modulator (partial agonist) | €90.00 | |
| 1567 | KRP 297 | PPARα agonist; PPARγ agonist | €110.00 | |
| 2814 | MHY 553 | PPARα agonist | €95.00 | |
| 2402 | MHY 908 | Dual PPARα/γ agonist, and potent inhibitor of mushroom tyrosinase | €95.00 | |
| 3255 | Pioglitazone hydrochloride | PPARγ agonist; antidiabetic drug | €50.00 | |
| 2443 | Rosiglitazone | PPARγ agonist; antidiabetic drug and stem cell differentiator | €95.00 | |
| 3999 | Saroglitazar magnesium | Potent dual PPARα/γ agonist | €160.00 | |
| 1227 | WY 14643 | PPARα agonist | €45.00 | |