MHY 908

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2402

CAS [1393371-39-5]

MF C17H14ClNO3S
MW 347.82

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

MHY 908

Description

Dual PPARα/γ agonist, and potent inhibitor of melanogenesis by inhibition of mushroom tyrosinase activity (IC50 value 8.19 μM). MHY908 more potently activated PPARα and PPARγ than fenofibrate and rosiglitazone, respectively, and enhanced the binding and transcriptional activity of PPARα and -γ in AC2F cells. It reduced serum glucose, triglyceride, and insulin levels, however increased adiponectin levels without body weight gain. In addition, MHY 908 significantly improved hepatic steatosis by enhancing CPT-1 levels. Remarkably, MHY-908 reduced endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK) activation, and subsequently reduced insulin resistance.

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5 mg €95.00 In Stock
25 mg €295.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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