A second member of the family of nuclear receptors (Nuclear class 1C, Thyroid Hormone Receptor-like) consists of peroxisome proliferator-activated receptors (PPAR, α, β, γ, and δ). They play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. The clinical importance of PPARs originates with fibrates and thiazolidinediones (TZDs), which respectively act on PPAR-α and PPAR-γ. They are used to ameliorate hyperlipidemia and hyperglycemia in subjects with type 2 diabetes mellitus. More recently, proof was found that PPARs also contribute to the regulation of certain physiological activities of the prostacyclin (PGI2) system in cardiovascular tissues[1].

[1] Peroxisome Proliferator-Activated Receptors (PPARS): A Target with a Broad Therapeutic Potential for Human Diseases: An Overview. M.P. Singh, D. Pathak, G.K. Sharma, C.S. Sharma. Pharmacologyonline 2011, 2, 58-89.

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Axon ID Name Description From price
3904 BAY-0069 Potent covalent PPARγ inverse agonist €90.00
3809 BAY-4931 Potent covalent PPARγ inverse agonist €120.00
1950 CDDO A potent multifunctional anti-tumor agent. PPAR-γ agonist €80.00
2114 CP 775146 Potent and selective PPARα agonist €85.00
2727 Elafibranor Dual PPARα/δ agonist €90.00
1628 GSK 3787 PPARδ antagonist €90.00
1237 GW 7647 PPARα agonist €95.00
2533 Hydroxypioglitazone Active metabolite of Pioglitazone (M-IV), a PPARγ agonist €180.00
2019 INT131 Selective PPARγ modulator (partial agonist) €90.00
1567 KRP 297 PPARα agonist; PPARγ agonist €110.00
2814 MHY 553 PPARα agonist €95.00
2402 MHY 908 Dual PPARα/γ agonist, and potent inhibitor of mushroom tyrosinase €95.00
3255 Pioglitazone hydrochloride PPARγ agonist; antidiabetic drug €50.00
2443 Rosiglitazone PPARγ agonist; antidiabetic drug and stem cell differentiator €95.00
3999 Saroglitazar magnesium Potent dual PPARα/γ agonist €160.00
1227 WY 14643 PPARα agonist €50.00

16 Item(s)

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