ATR
Similar to ATM, the ataxia-telangiectasia and Rad3-related (ATR; EC 2.7.11.1) protein and the DNA-activated protein kinase (DNA-PK) play an important role in responding to agents and extracellular stress that threaten the DNA replication process[1]. Both ATM and ATR kinases lie upstream in the DNA-damage-response signal-transduction network and are central to the entire DNA-damage response; they will be discussed in the corresponding section as well.
Ataxia telangiectasia kinase subclasses: ATM, ATR
[1] ATM,ATR andDNA-PK: initiators of the cellular genotoxic stress responses. J Yang, Y Yu, H Hamrick, PJ Duerksen-Hughes. Carcinogenesis 2003, 24, 1571-1580.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2345 | AZ 20 | Potent, orally active and selective inhibitor of ATR protein kinase | €105.00 | |
| 3134 | AZD6738 | Potent, selective, orally active and bioavailable ATR kinase inhibitor | €110.00 | |
| 2918 | BAY 1895344 | Potent, orally available and highly selective inhibitor of ATR protein kinase | €100.00 | |
| 1893 | VE 821 | Inhibitor of the DNA damage response kinase ATR | €80.00 | |
| 2452 | VE 822 | Selective ATR inhibitor that decreases survival of pancreatic cancer cells | €110.00 | |