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SCH23390 hydrochloride
Axon 4341
- Parent CAS: 87075-17-0
- Optical Purity: 99% e.e.
- Soluble in water, DMSO and EtOH
- MF: C17H18ClNO·HCl
- MW: 324.24
Description
SCH23390 hydrochloride is a highly potent and selective dopamine D1-like receptor antagonist with a Ki value of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH23390 is a highly recommended tool in researching the dopamine (DA) system, more specifically the D1 receptor, in neurological function and dysfunction. SCH23390 is (R)-(+)-enantiomer and its opposite (S)-(-)-enantiomer, SCH23388 hydrochloride (Axon 4404), is inactive biologically as a negative control.
More Information
| Parent CAS No. | 87075-17-0 |
|---|---|
| Chemical Name | (R)-8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrochloride |
| SMILES | [C@H]1(C2=CC(O)=C(Cl)C=C2CCN(C)C1)C1=CC=CC=C1.Cl |&1:0,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1 |
| InChiKey | OYCAEWMSOPMASE-XFULWGLBSA-N |
| CID | 11957535 |
| Short Description | D1/D5 antagonist |
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| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1236 | SKF 83566 hydrobromide |
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| 1405 | NNC 756 |
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| 4404 | SCH23388 hydrochloride |
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