Bulk Inquiry
BMS-684
Axon 4109
CAS:
313552-29-3
Purity:
99%
- Soluble in DNMSO
- MF: C27H26N4O3
- MW: 454.52
Description
BMS-684 is a selective DGKα inhibitor with an IC50 value of 15 nM. BMS-684 inhibited DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ and did not inhibit any of the other seven DGK isozymes.
More Information
| Parent CAS No. | 313552-29-3 |
|---|---|
| Chemical Name | 4-(4-Benzhydrylpiperazin-1-yl)-1-methyl-3-nitroquinolin-2(1H)-one |
| MFCD | N.A. |
| Short Description | DGKα inhibitor |
References
- M Wichroski et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15(719):eadh1892.
- L Chupak et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.
Other Categories
Get a Quote for
Loading...