BC-1215 is a selective and reversible Fbxo3 inhibitor. BC-1215 reduced TRAF protein levels, which potently inhibited cytokine release from human blood mononuclear cells. BC-1215 effectively lessened the severity of viral pneumonia, septic shock, colitis, and cytokine-driven inflammation systemically in murine models.

KEYWORDS: BC-1215 | Supplier | Fbxo3 inhibitor | BC1215 | BC 1215 | CAS [1507370-20-8] | [1507370-44-6] | Non Selective (Ubiquitin peptides) | Ubiquitin Ligase (E3; other) | Inhibitor | Enzymes | TNFR-associated factor | TRAF | Immunity | Skp-Cullin1-F box | SCF