Based on 5 reference(s) in Google Scholar 8 10 5

Axon 3846

CAS [1358099-18-9]

MF C26H31N7O
MW 457.57

  • Purity: 99%
  • Soluble in DMSO and EtOH



C25-140 is a first-in-class TRAF6–Ubc13 inhibitor which reduces TRAF6–Ubc13 activity both in vitro and in cells. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. Moreover, C25-140 ameliorated inflammation and improved disease outcomes of autoimmune psoriasis and rheumatoid arthritis in preclinical in vivo mouse models.

Keywords: C25-140 | Supplier | TRAF6–Ubc13 inhibitor | C 25-140 | C-25-140 | CAS [1358099-18-9] | NF-κB pathway | Ubiquitin Ligase (E3; other) | Inhibitor | Enzymes | Autoimmune disease | NF receptor-associated factor 6 | Psoriasis | Rheumatoid arthritis

Size Unit Price Stock
10 mg €160.00 In Stock
50 mg €640.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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