TAK-981 oxalate - Subasumstat oxalate

Based on 12 reference(s) in Google Scholar 8 10 12

Axon 3797

CAS [N.A.]

MF C25H28ClN5O5S2
MW 668.14

Purity: 99%
Optical purity: 99%
Soluble in DMSO

TAK-981 oxalate

Description

TAK-981 oxalate is a first-in-class selective small molecule inhibitor of SUMOylation and an immuno-oncology agent. It targets and covalently binds to the small ubiquitin-like modifier (SUMO) protein, forming an adduct (TAK-981-SUMO adduct).

M Khattar et al. TAK-981: A first in class SUMO inhibitor in Phase 1 trials that promotes dendritic cell activation, antigen-presentation, and T cell priming. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3;AACR; Cancer Res 2019;79 (13 Suppl): Abstract nr 3252.

Inhibitor of SUMOylation

Chemical name

((1R,2S,4R)-4-(5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-ylamino)-2-hydroxycyclopentyl)methyl sulfamate oxalate

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1858276-04-6]

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TAK-981 oxalate - Subasumstat oxalate

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TAK-981 oxalate - Subasumstat oxalate

Description

Chemical name

Source information

Parent CAS No.

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