JQKD82 dihydrochloride is a cell-permeable and selective KDM5 inhibitor which increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a prodrug-type KDM5 inhibitor which delivers the active binding molecule KDM5-C49 to potently block KDM5 function in multiple myeloma cells both in vitro and in vivo (IC50 value of 0.42 μM in MM.1S cells).

KEYWORDS: JQKD82 dihydrochloride | Supplier | KDM5 inhibitor | JQKD 82 | JQKD-82 | CAS [2863635-05-4] | [2410512-38-6] | [2863676-87-1] | Histone | Histone demethylase | Inhibitor | Enzymes | Lysine Demethylase 5A | Multiple myeloma | H3K4me3