JQKD82 dihydrochloride

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3783

CAS [2863635-05-4]

MF C27H40N4O5.2HCl
MW 573.55

  • Purity: 99%
  • Soluble in water, DMSO and EtOH

JQKD82 dihydrochloride


JQKD82 dihydrochloride is a cell-permeable and selective KDM5 inhibitor which increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a prodrug-type KDM5 inhibitor which delivers the active binding molecule KDM5-C49 to potently block KDM5 function in multiple myeloma cells both in vitro and in vivo (IC50 value of 0.42 μM in MM.1S cells).

KEYWORDS: JQKD82 dihydrochloride | Supplier | KDM5 inhibitor | JQKD 82 | JQKD-82 | CAS [2863635-05-4] | [2410512-38-6] | [2863676-87-1] | Histone | Histone demethylase | Inhibitor | Enzymes | Lysine Demethylase 5A | Multiple myeloma | H3K4me3

Cell-permeable and selective KDM5 inhibitor

Chemical name

2,4-Diisopropoxyphenyl 2-((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethylamino)methyl)isonicotinate dihydrochloride

Parent CAS No.


Size Unit Price Stock
5 mg €190.00 In Stock
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Size Unit Price Stock
2 x 5 mg €340.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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