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(R)-AS-1
Axon 3777
CAS:
2506367-95-7
- Optical Purity: 98.1% e.e.
- Soluble in DMSO and EtOH
- MF: C14H16N2O3
- MW: 260.29
Description
(R)-AS-1 is a first-in-class highly selective and orally bioavailable positive allosteric modulator (PAM) of EAAT2. (R)-AS-1 is shown to have robust antiseizure properties in a broad range of epilepsy models in mice and zebrafish, as well as an excellent tolerability and safety profile in both in vitro and in vivo studies.
More Information
| Parent CAS No. | 2506367-95-7 |
|---|---|
| Chemical Name | (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide |
| SMILES | [C@H](C)(N1C(=O)CCC1=O)C(=O)NCC1C=CC=CC=1 |&1:0,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C14H16N2O3/c1-10(16-12(17)7-8-13(16)18)14(19)15-9-11-5-3-2-4-6-11/h2-6,10H,7-9H2,1H3,(H,15,19)/t10-/m1/s1 |
| InChiKey | XVSYJYYNUSOPAQ-SNVBAGLBSA-N |
| CID | 155213164 |
| Short Description | EAAT2 PAM |
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