Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3777

CAS [2506367-95-7]

MF C14H16N2O3
MW 260.29

  • Purity: 100%
  • Optical purity: 98% e.e.
  • Soluble in DMSO and EtOH



(R)-AS-1 is a first-in-class highly selective and orally bioavailable positive allosteric modulator (PAM) of EAAT2. (R)-AS-1 is shown to have robust antiseizure properties in a broad range of epilepsy models in mice and zebrafish, as well as an excellent tolerability and safety profile in both in vitro and in vivo studies.

KEYWORDS: (R)-AS-1 | EAAT2 PAM | (R)-AS1 | (R)-AS 1 | CAS [2506367-95-7] | Glutamate | EAAT | PAM | Proteins | Antiseizure | Epilepsy | Excitatory amino acid transporter-2 | Antiseizure drug

Size Unit Price Stock
10 mg €145.00 In Stock
50 mg €580.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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