(R)-AS-1 is a first-in-class highly selective and orally bioavailable positive allosteric modulator (PAM) of EAAT2. (R)-AS-1 is shown to have robust antiseizure properties in a broad range of epilepsy models in mice and zebrafish, as well as an excellent tolerability and safety profile in both in vitro and in vivo studies.

KEYWORDS: (R)-AS-1 | EAAT2 PAM | (R)-AS1 | (R)-AS 1 | CAS [2506367-95-7] | Glutamate | EAAT | PAM | Proteins | Antiseizure | Epilepsy | Excitatory amino acid transporter-2 | Antiseizure drug