LockdownPro is an ester-modified variant of Lockdown, which is a potent, selective, cell-active, reversible, and non-competitive PPM1F inhibitor. LockdownPro displayed increased membrane permeability and prodrug-like properties. Importantly, LockdownPro efficiently suppressed tissue invasion of PPM1F-overexpressing human cancer cells in the chicken chorioallantoic membrane tumor assay.

KEYWORDS: LockdownPro | Supplier | PPM1F inhibitor | CAS [2985814-80-8] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | PPM | Inhibitor | Enzymes