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Nitisinone - Nitisone | NTBC | SC0735

Based on 345 reference(s) in Google Scholar 8 10 345

Axon 3662

CAS [104206-65-7]

MF C14H10F3NO5
MW 329.23

Purity: 99%
Soluble in DMSO and EtOH

Nitisinone

Description

Nitisinone is a potent, reversible and orally bioavailable inhibitor of 4-hydroxyphenyl pyruvate dioxygenase (4-HPPD) with an IC50 value of 173 nM.

KEYWORDS: Nitisinone | Supplier | 4-HPPD inhibitor | Nitisone;NTBC;SC0735 | NTBC | SC0735 | SC 0735 | SC-0735 | CAS [104206-65-7] | 4-Hydroxyphenylpyruvate | 4-HPPD | Inhibitor | Enzymes | Hereditary tyrosinemia type 1 | HT1 | Alkaptonuria

AC Aktuglu-Zeybek et al. Nitisinone: a review. Orphan Drugs: Research and Reviews. 2017 January 31; 7: 25-35.

M Laschi et al. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria. ChemMedChem. 2016 Apr 5;11(7):674-8.

Diabetes & Metabolism EC 1.13.11.27

Potent, reversible and orally bioavailable 4-HPPD inhibitor

Chemical name

2-(2-Nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione

Parent CAS No.

[104206-65-7]

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Size	Unit Price	Stock
50 mg	€50.00	In Stock

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2 x 50 mg	€70.00	In Stock

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