JavaScript seems to be disabled in your browser.
You must have JavaScript enabled in your browser to utilize the functionality of this website.

Axon Medchem

All

Home
Products
- Shop By Category
- Featured Products
- Shop By Alphabet
  - A
  - B
  - C
  - D
  - E
  - F
  - G
  - H
  - I
  - J
  - K
  - L
  - M
  - N
  - O
  - P
  - Q
  - R
  - S
  - T
  - U
  - V
  - W
  - X
  - Y
  - Z
  - #
Support
- - Customer Support
  - Customer Services
Contact
- About Axon Medchem
- Contact Us

VU6005649

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3487

CAS [2137047-43-7]

MF C16H12F5N3O
MW 357.28

Purity: 99%
Soluble in DMSO and EtOH

VU6005649

Description

VU6005649 is a brain penetrant mGlu 7/8 receptor PAM with EC50 values of 649 nM and 2.6 μM for mGluR7 and mGluR8, respectively.

KEYWORDS: VU6005649 | Supplier | mGluR7/8 PAM | VU 6005649 | VU-6005649 | CAS [2137047-43-7] | Glutamate | mGluR7 | mGluR8 | PAM | Receptors | Rett syndrome

M Abe et al. Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines. ACS Med Chem Lett. 2017 Sep 1;8(10):1110-1115.

CNS mGluR8 C3 mGluR7

Brain penetrant PAM of mGluR7/8

Chemical name

3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

Parent CAS No.

[2137047-43-7]

Order

Size	Unit Price	Stock
5 mg	€85.00	In Stock
25 mg	€300.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock

Need more? Bulk Inquiry

Please wait...