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Axon 3475
CAS [54863-37-5]
MF C4H7NO2SMW 133.17
OLT1177 is a selective and orally active NLRP3 inflammasome inhibitor which reverses the metabolic cost of inflammation. In vitro, nanomolar concentrations of OLT1177 reduced IL-1β and IL-18 release following canonical and noncanonical NLRP3 inflammasome activation. The molecule showed no effect on the NLRC4 and AIM2 inflammasomes, suggesting specificity for NLRP3.
KEYWORDS: OLT1177 | Supplier | NLRP3 inhibitor | Dapansutrile | OLT 1177 | OLT-1177 | CAS [54863-37-5] | NF-κB Pathway | NOD1 | Inhibitor | Receptors | Autoimmune encephalomyelitis | Cryopyrin
3-(Methylsulfonyl)propanenitrile
[54863-37-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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