OLT1177 - Dapansutrile

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3475

CAS [54863-37-5]

MW 133.17

  • Purity: 99%
  • Soluble in water, DMSO and EtOH



OLT1177 is a selective and orally active NLRP3 inflammasome inhibitor which reverses the metabolic cost of inflammation. In vitro, nanomolar concentrations of OLT1177 reduced IL-1β and IL-18 release following canonical and noncanonical NLRP3 inflammasome activation. The molecule showed no effect on the NLRC4 and AIM2 inflammasomes, suggesting specificity for NLRP3.

KEYWORDS: OLT1177 | Supplier | NLRP3 inhibitor | Dapansutrile | OLT 1177 | OLT-1177 | CAS [54863-37-5] | NF-κB Pathway | NOD1 | Inhibitor | Receptors | Autoimmune encephalomyelitis | Cryopyrin

Size Unit Price Stock
10 mg €70.00 In Stock
50 mg €240.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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