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IMT1B
- LDC203974
Axon 3417
CAS:
2304621-06-3
- Optical Purity: 100% e.e.
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C24H21ClFNO6
- MW: 473.88
Description
IMT1B (LDC203974) is a first-in-class, potent and highly specific allosteric inhibitor of human mitochondrial RNA polymerase (POLRMT). POLRMT is essential for mitochondrial DNA (mtDNA) transcription and the biogenesis of the oxidative phosphorylation (OXPHOS) system. Inhibition of POLRMT by IMT1B disrupts mitochondrial gene expression and mitochondrial function.
POLRMT plays a central role in mitochondrial transcription and energy metabolism by regulating expression of mitochondrial-encoded components of the respiratory chain. IMT1B has demonstrated potent antitumor activity in preclinical mouse cancer models and is a valuable tool for studying mitochondrial biology, OXPHOS regulation, and cancer metabolism.
Key Features
- First-in-class POLRMT inhibitor
- Potent and highly specific allosteric mechanism
- Inhibits mitochondrial DNA transcription
- Disrupts OXPHOS system biogenesis
- Demonstrates antitumor activity in preclinical models
Applications
- POLRMT and mitochondrial transcription research
- Mitochondrial biology studies
- OXPHOS and energy metabolism investigations
- Cancer metabolism research
- Mitochondrial target validation studies
More Information
| Parent CAS No. | 2304621-06-3 |
|---|---|
| Chemical Name | (S)-1-((R)-2-(4-(2-Chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yloxy)propanoyl)piperidine-3-carboxylic acid |
| SMILES | C1C(C2=CC(=O)OC3C=C(O[C@@H](C(=O)N4CCC[C@H](C(=O)O)C4)C)C=CC2=3)=C(Cl)C=C(F)C=1 |&1:11,18,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H21ClFNO6/c1-13(23(29)27-8-2-3-14(12-27)24(30)31)32-16-5-7-18-19(11-22(28)33-21(18)10-16)17-6-4-15(26)9-20(17)25/h4-7,9-11,13-14H,2-3,8,12H2,1H3,(H,30,31)/t13-,14+/m1/s1 |
| InChiKey | PFEKWBKJUBCXDT-KGLIPLIRSA-N |
| CID | 138490769 |
| Short Description | POLRMT inhibitor |
IMT1B
LDC203974
LDC 203974
LDC-203974
POLRMT inhibitor
mitochondrial RNA polymerase inhibitor
POLRMT
mitochondrial transcription
mtDNA transcription
mitochondrial DNA
OXPHOS
oxidative phosphorylation
mitochondrial biogenesis
energy metabolism
cancer metabolism
mitochondrial function
RNAP1
mitochondrial gene expression
CAS 2304621-06-3
Axon Medchem
Axon 3417
DNA-RNA
Enzymes
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