IMT1B - LDC203974

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3417

CAS [2304621-06-3]

MW 473.88

  • Purity: 98%
  • Optical purity: 100% e.e.
  • Soluble in 0.1N NaOH(aq), DMSO and EtOH



IMT1B is a first-in-class, potent and highly specific allosteric inhibitor of the human mitochondrial RNA polymerase (POLRMT), which is essential for mtDNA transcription and biogenesis of the oxidative phosphorylation (OXPHOS) system. IMT1B shows potent effects for the treatment of cancer in preclinical mouse models.

KEYWORDS: IMT1B | Supplier | POLRMT inhibitor | LDC203974 | LDC 203974 | LDC-203974 | CAS [2304621-06-3] | DNA-RNA | RNAP1 | Inhibitor | Enzymes | OXPHOS

First-in-class, potent and highly specific allosteric POLRMT inhibitor

Chemical name

(S)-1-((R)-2-(4-(2-Chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yloxy)propanoyl)piperidine-3-carboxylic acid

Parent CAS No.


Size Unit Price Stock
2 mg €130.00 In Stock
5 mg €230.00 In Stock
25 mg €790.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €400.00 In Stock
2 x 25 mg €1,260.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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