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Fezolinetant
- ESN364
Axon 3403
CAS:
1629229-37-3
- Optical Purity: 100% e.e.
- Soluble in DMSO and EtOH
- MF: C16H15FN6OS
- MW: 358.39
Description
Fezolinetant is an orally bioavailable neurokinin-3 receptor (NK3R) antagonist with a pKi value of 7.6 and a pIC50 value of 7.7.
More Information
| Parent CAS No. | 1629229-37-3 |
|---|---|
| Chemical Name | (R)-(4-Fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone |
| SMILES | C1N(C(C2C=CC(F)=CC=2)=O)[C@H](C)C2=NN=C(C3SN=C(C)N=3)N2C1 |&1:11,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1 |
| InChiKey | PPSNFPASKFYPMN-SECBINFHSA-N |
| CID | 117604931 |
| Short Description | NK3R antagonist |
References
- GL Fraser et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25.
- HR Hoveyda et al. Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II). ACS Med Chem Lett. 2015 May 19;6(7):736-40.
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