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Empagliflozin
- BI10773
Axon 3367
CAS:
864070-44-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C23H27ClO7
- MW: 450.91
Description
Empagliflozin is a potent and selective SGLT-2 inhibitor (IC50 value of 3.1 nM for hSGLT-2).
More Information
| Parent CAS No. | 864070-44-0 |
|---|---|
| Chemical Name | (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| SMILES | [C@H]1(CO)O[C@@H](C2C=CC(Cl)=C(CC3=CC=C(O[C@@H]4COCC4)C=C3)C=2)[C@H](O)[C@@H](O)[C@@H]1O |&1:0,4,17,25,27,29,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1 |
| InChiKey | OBWASQILIWPZMG-QZMOQZSNSA-N |
| CID | 11949646 |
| Short Description | SGLT2 inhibitor |
References
- L Thomas et al. Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats. Diabetes Obes Metab. 2012 Jan;14(1):94-6.
- R Grempler et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90.
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