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Verteporfin
- Visudyne
- Soluble in DMSO
- MF: C41H42N4O8
- MW: 718.79
Description
Verteporfin is an inhibitor of TEAD-YAP association and YAP-induced liver overgrowth. Moreover, Verteporfin treatment inhibited gastric carcinomas tumor growth in vivo. Also, Verteporfin is used clinically as a photosensitizer in photodynamic therapy for neovascular macular degeneration, where it is activated by a special wavelength laser light to generate reactive oxygen radicals that eliminate the abnormal blood vessels.
More Information
| Parent CAS No. | 129497-78-5 |
|---|---|
| Chemical Name | (4R,4aS)-rel-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester |
| MFCD | MFCD11982858 |
| Short Description | YAP inhibitor |
References
- Y Liu-Chittenden et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012 Jun 15;26(12):1300-5.
- F Gibault et al. Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway. ChemMedChem. 2017 Jun 21;12(12):954-961.
- J Giraud et al. Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. Int J Cancer. 2020 Apr 15;146(8):2255-2267.
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