Avibactam sodium - NXL104

Based on 509 reference(s) in Google Scholar 8 10 509

Axon 3299

CAS [1192491-61-4]

MF C7H10N3NaO6S
MW 287.23

Purity: 98%
Optical purity: Optically pure
Soluble in water and DMSO

Avibactam sodium

Description

Avibactam sodium is a covalent and reversible β-lactamase inhibitor with potent activity against both class A and class C enzymes (IC50 value of 38 nM for KPC-2).

T Stachyra et al. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases. J Antimicrob Chemother 2009 Aug;64(2):326-9.

DE Ehmann et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

Covalent, reversible inhibitor of β-lactamase

Chemical name

Sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

Parent CAS No.

[1192500-31-4]

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