LEI-301 is a potent inhibitor for the PLAAT family members with pIC50 values of 7.3, 6.6, 7.3 and 7.4 for PLAAT2, PLAAT3, PLAAT4 and PLAAT5, respectively. LEI-301 was selective over the proteins of the endocannabinoid system (ECS). Moreover, LEI-301 reduced the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5.

KEYWORDS: LEI-301 | Supplier | PLAAT inhibitor | LEI301 | LEI 301 | CAS [2571585-09-4] | Phospholipid metabolism | Inhibitor | Enzymes | PLAAT | Phospholipase A and acyltransferase | LRAT | Lecithin retinol acyltransferase | NAPE | NAE