Metapristone - RU42633

Based on 48 reference(s) in Google Scholar 8 10 48

Axon 3268

CAS [104004-96-8]

MF C28H33NO2
MW 415.57

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq), DMSO and EtOH
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Metapristone

Description

Metapristone, the primary metabolite of RU486 (Axon 1502), suppressed NSCLC proliferation by promoting apoptosis via decrease the cellular EGFR-mediated PI3K/AKT pathways. In addition, metapristone inhibited anti-apoptotic marker Bcl-2, and activated pro-apoptotic key signaling proteins caspase-3, and poly (ADP-ribose) polymerase. Metapristone induced A549 and H1975 cell cycle via arrest at the G0-G1 stage. Moreover, metapristone inhibited endometrial cancer cell growth through suppressing cell proliferation and activating cell apoptosis-related signaling pathway. Mechanically, metapristone regulated miR-492 and its new target genes Klf5 and Nrf1 in vitro and in vivo to treat endometrial cancer.

KEYWORDS: Metapristone.Supplier | Metabolite Mifepristone | RU42633 | RU 42633 | RU-42633 | CAS [104004-96-8] | Progesterone (PR) | Metabolite | Receptors

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10 mg €110.00 In Stock
50 mg €330.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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