XAF-1407

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3265

CAS [N.A.]

MF C28H37N5O2S
MW 507.69

Purity: 99%
Soluble in 0.1N HCl(aq), DMSO and EtOH

XAF-1407

Description

XAF-1407 is a potent and highly selective inhibitor of the ion channels formed by Kir3.1/3.4 heterotetramers and Kir3.4 homotetramers that carry the IKACh current (IC50 values of 1.1 and 3.2 nM, respectively).

MF Fenner et al. Effect of selective I K,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation. Br J Pharmacol. 2020 May 20.

Cardiovascular Non Selective (KCNA5; KCND3; KCNJ5; KCNE1)

Potent and highly selective IKACh inhibitor

Chemical name

3-Methyl-1-(5-phenyl-4-(4-((2-(pyrrolidin-1-yl)ethoxy)methyl)piperidin-1-yl)thieno[2,3-d]pyrimidin-6-yl)azetidin-3-ol

Parent CAS No.

[N.A.]

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2243	AVE 0118 hydrochloride	Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents)		€120.00

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