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MYCi975
- NUCC-0200975
- Soluble in DMSO
- MF: C25H16Cl2F6N2O2
- MW: 561.3
Description
MYCi975 is a MYC inhibitor which disrupts MYC/MAX interaction while also decreasing MYC protein stability. This dual mechanism of action leads to significant inhibition of MYC-dependent cancer-cell proliferation in vitro with suppression of global MYC target gene expression and inhibition of tumor growth in vivo. Moreover, MYCi975 showed an excellent pharmacokinetic profile, with a long terminal half-life, high peak plasma concentration, and tumor penetration, as demonstrated by pharmacodynamic markers, such as MYC T58 phosphorylation. MYCi975 enhanced immunotherapy.
More Information
| Parent CAS No. | 2289691-01-4 |
|---|---|
| Chemical Name | 4'-Chloro-6-(4-chlorobenzyloxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3'-(trifluoromethyl)biphenyl-2-ol |
| SMILES | C1C=C(OCC2C=CC(Cl)=CC=2)C(C2C=C(C(F)(F)F)C(Cl)=CC=2)=C(O)C=1C1=CC(C(F)(F)F)=NN1C |
| MFCD | N.A. |
| InChi | InChI=1S/C25H16Cl2F6N2O2/c1-35-19(11-21(34-35)25(31,32)33)16-7-9-20(37-12-13-2-5-15(26)6-3-13)22(23(16)36)14-4-8-18(27)17(10-14)24(28,29)30/h2-11,36H,12H2,1H3 |
| InChiKey | VSDFDVBYONIJLD-UHFFFAOYSA-N |
| CID | 139600320 |
| Short Description | MYC inhibitor |
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