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Axon 3229
CAS [2289691-01-4]
MF C25H16Cl2F6N2O2MW 561.30
MYCi975 is a MYC inhibitor which disrupts MYC/MAX interaction while also decreasing MYC protein stability. This dual mechanism of action leads to significant inhibition of MYC-dependent cancer-cell proliferation in vitro with suppression of global MYC target gene expression and inhibition of tumor growth in vivo. Moreover, MYCi975 showed an excellent pharmacokinetic profile, with a long terminal half-life, high peak plasma concentration, and tumor penetration, as demonstrated by pharmacodynamic markers, such as MYC T58 phosphorylation. MYCi975 enhanced immunotherapy.
KEYWORDS: MYCi975 | supplier | MYC inhibitor | NUCC-0200975 | NUCC 0200975 | NUCC0200975 | CAS [2289691-01-4] | DNA-RNA | c-MYC | Inhibitor | Transcription Factors
4'-Chloro-6-(4-chlorobenzyloxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3'-(trifluoromethyl)biphenyl-2-ol
[2289691-01-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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