Obeticholic acid - 6-ECDCA | INT-747

Based on 717 reference(s) in Google Scholar 8 10 717

Axon 3174

CAS [459789-99-2]

MF C26H44O4
MW 420.63

  • Purity: 98%
  • Optical purity: Opically pure
  • Soluble in 0.1N NaOH(aq) and DMSO
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Obeticholic acid

Description

Obeticholic acid is a very potent and selective FXR agonist (EC50 value of 99 nM) and is shown to be endowed with anticholeretic activity in an in vivo rat model of cholestasis.

KEYWORDS: Obeticholic acid | supplier | FXR agonist | 6-ECDCA | INT-747 | 6 ECDCA | 6ECDCA | INT 747 | INT747 | CAS [459789-99-2] | [2061890-61-5] | Chenodeoxycholic acid | FXR | Agonist | Receptors | Cholestasis

Potent and selective FXR agonist

Chemical name

(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-Ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

Parent CAS No.

[459789-99-2]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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