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KUS121
Axon 3143
- Parent CAS: 1357245-09-0
Purity:
98%
- Soluble in water and DMSO
- MF: C22H16FN4NaO3S
- MW: 458.44
Description
KUS121 is an ATPase inhibitor of valosin-containing protein (VCP) with an IC50 value of 330 nM; Neuroprotectant.
More Information
| Parent CAS No. | 1357245-09-0 |
|---|---|
| Chemical Name | Sodium (E)-4-amino-3-((6-(4-fluoro-2-methylphenyl)pyridin-3-yl)diazenyl)naphthalene-1-sulfonate |
| SMILES | C1C=C2C(N)=C(/N=N/C3C=CC(C4C=CC(F)=CC=4C)=NC=3)C=C(S([O-])(=O)=O)C2=CC=1.[Na+] |
| MFCD | N.A. |
| InChi | InChI=1S/C22H17FN4O3S.Na/c1-13-10-14(23)6-8-16(13)19-9-7-15(12-25-19)26-27-20-11-21(31(28,29)30)17-4-2-3-5-18(17)22(20)24;/h2-12H,24H2,1H3,(H,28,29,30);/q;+1/p-1/b27-26+; |
| InChiKey | OEEZHMGRDYLKGJ-JGUILPGDSA-M |
| CID | 56955396 |
| Short Description | VCP inhibitor |
References
- H Kinoshita et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019;9(1):11519.
- HO Ikeda et al. Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial. PLoS One. 2020;15(2):e0229068.
- HO Ikeda et al. Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa. Sci Rep. 2014;4:5970.
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