KUS121

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3143

CAS [1357164-52-3]

MF C22H16FN4NaO3S
MW 458.44

Purity: 98%
Soluble in water and DMSO

KUS121

Description

KUS121 is an ATPase inhibitor of valosin-containing protein (VCP) with an IC50 value of 330 nM; Neuroprotectant.

H Kinoshita et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019;9(1):11519.

HO Ikeda et al. Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial. PLoS One. 2020;15(2):e0229068.

HO Ikeda et al. Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa. Sci Rep. 2014;4:5970.

ATPase inhibitor of valosin-containing protein (VCP)

Chemical name

Sodium (E)-4-amino-3-((6-(4-fluoro-2-methylphenyl)pyridin-3-yl)diazenyl)naphthalene-1-sulfonate

Parent CAS No.

[1357245-09-0]

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