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CB-5083

Name: CB-5083
SKU: 4170

Axon 4170

CAS: 1542705-92-9

Purity: 98%

Soluble in DMSO and EtOH

MF: C24H23N5O2
MW: 413.47

Description

CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of p97 AAA ATPase with an IC50 value of 11 nM.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

ATPase (p97)

Parent CAS No.	1542705-92-9
Chemical Name	1-(4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
MFCD	MFCD28963914
Short Description	p97 ATPase inhibitor

CB-5083 p97 ATPase inhibitor CB5083 CB 5083 CAS 1542705-92-9 Axon Medchem Axon 4170 ATP ATPase (p97) Inhibitor Enzymes Ubiquitin-proteasome system UPS ERAD Multiple myeloma Solid tumor VCP Supplier Vendor

References

HJ Zhou et al. Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). J Med Chem. 2015 Dec 24;58(24):9480-97.

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CB-5083

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