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Dapagliflozin
- BMS-512148
Axon 3121
CAS:
461432-26-8
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C21H25ClO6
- MW: 408.87
Description
Dapagliflozin is a potent and selective hSGLT2 inhibitor (EC50 value of 1.1 nM) which reduced blood glucose levels in a dose-dependent manner by as much as 55% in hyperglycemic streptozotocin (STZ) rats.
More Information
| Parent CAS No. | 461432-26-8 |
|---|---|
| Chemical Name | (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| SMILES | [C@H]1(CO)O[C@@H](C2C=CC(Cl)=C(CC3C=CC(OCC)=CC=3)C=2)[C@H](O)[C@@H](O)[C@@H]1O |&1:0,4,22,24,26,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1 |
| InChiKey | JVHXJTBJCFBINQ-ADAARDCZSA-N |
| CID | 9887712 |
| Short Description | SGLT2 inhibitor |
References
- W Meng et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem. 2008 Mar 13;51(5):1145-9.
- M Obermeier et al. In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans. Drug Metab Dispos. 2010 Mar;38(3):405-14.
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