LIT-001

LIT-001 is a potent, nonpeptide agonist of oxytocin receptor (OTR) with reported EC50 values of 25 nM at the human receptor and 18 nM at the mouse receptor. It activates oxytocin receptor-dependent signaling while displaying substantially weaker activity at closely related vasopressin receptors under the reported assay conditions.

LIT-001 provides a systemically active alternative to peptide oxytocin for studying oxytocin receptor pharmacology, social behavior and central neuroendocrine signaling. Peripheral administration improved social-interaction phenotypes in mouse models, making it useful for linking receptor activation to behavioral and neuronal outcomes while avoiding the rapid degradation of native oxytocin.

Key Features

• Potent nonpeptide oxytocin receptor agonist
• EC50: 25 nM at human OTR
• High efficacy at human and mouse oxytocin receptors
• Systemically active pharmacological probe

Applications

• Oxytocin receptor signaling studies
• Social-behavior and neuroendocrine research
• GPCR activation and receptor-selectivity assays
• Animal models of social-interaction deficits