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FTBMT
- Soluble in DMSO
- MF: C19H16F4N4O
- MW: 392.35
Description
FTBMT is a potent, selective, and orally available GPR52 agonist with an EC50 value of 75 nM. FTBMT demonstrates both in vitro and in vivo activity, including activation of cAMP signaling in striatal neurons.
FTBMT exhibits high metabolic stability across multiple species and shows excellent pharmacokinetic properties in rats, making it a valuable tool compound for studies on GPR52 signaling and CNS disorders.
Key Features
- Potent and selective GPR52 agonist
- EC50: 75 nM
- Orally available compound
- Activates cAMP signaling in striatal neurons
- Demonstrates in vitro and in vivo activity
- High metabolic stability and favorable PK properties
Applications
- G Protein-Coupled Receptor (GPR52) signaling research
- cAMP pathway studies
- Striatal neuron biology research
- Schizophrenia and antipsychotic research
- CNS drug discovery and pharmacology studies
More Information
| Parent CAS No. | 1358575-02-6 |
|---|---|
| Chemical Name | 4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide |
| SMILES | C1(C(=O)N)C(C)=CC(N2N=C(CC3C=C(C(F)(F)F)C=C(F)C=3)N=C2C)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H16F4N4O/c1-10-5-15(3-4-16(10)18(24)28)27-11(2)25-17(26-27)8-12-6-13(19(21,22)23)9-14(20)7-12/h3-7,9H,8H2,1-2H3,(H2,24,28) |
| InChiKey | TYXSIXOYTBHZFA-UHFFFAOYSA-N |
| CID | 56649300 |
| Short Description | GPR52 agonist |
References
- K Tokumaru et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115.
- K Nishiyama et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.
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