Exo1 is a chemical inhibitor of the exocytic pathway with an IC50 value of 20 µM. Exo1 induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus acutely inhibiting the traffic emanating from the endoplasmic reticulum. Moreover, Exo1 induces the rapid release of ADP-ribosylation factor (ARF) 1 from Golgi membranes but has less effect on the organization of the trans-Golgi network.

KEYWORDS: Exo1 | supplier | Exocytic pathway inhibitor | Exo 1 | Exo-1 | CAS [75541-83-2] | Golgi apparatus | Inhibitor | Proteins | ADP-ribosylation factor 1 |  ARF 1 | Endoplasmic reticulum