WNK Inhibitor 11

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2896

CAS [2123489-30-3]

MF C21H21Cl2N5OS
MW 462.40

Purity: 98%
Soluble in DMSO

WNK Inhibitor 11

Description

Selective allosteric WNK1 inhibitor (IC50 value of 0.004 µM) with nearly 1000-fold selectivity for WNK1 vs WNK4 and 57-fold selectivity for WNK1 vs WNK2.

K Yamada et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107.

Cardiovascular EC 2.7.11.1 WNK

Selective allosteric inhibitor of WNK1

Chemical name

(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone

Parent CAS No.

[2123489-30-3]

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WNK Inhibitor 11

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WNK Inhibitor 11

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