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ESI-08

 - HJC-1-65
Axon 2847
CAS:  301177-43-5
Purity:  99%
  • Soluble in DMSO
  • MF:  C20H23N3OS
  • MW:  353.48

Description

ESI-08 is a selective EPAC antagonist, which is capable of completely inhibiting both EPAC1 and EPAC2 activity (IC50 value of 8.4 μM for EPAC2) without inhibition of cAMP-mediated PKA activation.

More Information

Parent CAS No. 301177-43-5
Chemical Name 4-Cyclohexyl-2-(2,5-dimethylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
SMILES C1(C#N)C(=O)NC(SCC2C(C)=CC=C(C)C=2)=NC=1C1CCCCC1
MFCD N.A.
InChi InChI=1S/C20H23N3OS/c1-13-8-9-14(2)16(10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)
InChiKey LSHOSZQLVLPEGG-UHFFFAOYSA-N
CID 135473051
Short Description EPAC antagonist

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