Since EPAC (exchange protein directly activated by cAMP) proteins interact with a plethora of intracellular signaling molecules, EPAC1 and EPAC2 regulate a wide variety of biologic responses and functions. Alterations in the EPAC signalosome have been implicated in the pathophysiology of a number of diseases such as diabetes, cognitive impairment, renal and heart failure, (pulmonary) hypertension, asthma, and chronic obstructive pulmonary disease. Further insights into the cAMP dynamics executed by the EPAC signalosome will help to optimize the pharmacological treatment of these diseases. In addition, specific targeting of the EPAC signaling pathway may open new therapeutic strategies in the pharmacological treatment of these diseases.[1]

[1] M. Schmidt et al. Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol Rev. 2013 Feb 27;65(2):670-709.

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Axon ID Name Description From price
2830 (R)-CE3F4 Potent inhibitor of EPAC1 €120.00
2929 CE3F4 Inhibitor of EPAC1 €95.00
2847 ESI-08 Selective EPAC antagonist €140.00
3326 HJC0197 Potent EPAC antagonist €90.00
2730 HJC0350 Highly potent and selective EPAC2 antagonist €95.00

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