Major metabolite of Clozapine (Axon 1146). N-Desmethylclozapine is a relatively potent and efficacious partial agonist at the D2 and D3 dopamine receptors, while showing inverse agonism at the 5-HT2A receptor. Moreover, N-Desmethylclozapine is a potent partial agonist at the muscarinic M1 receptor and a selective agonist at δ opioid receptor.

KEYWORDS: N-Desmethylclozapine | supplier | Clozapine metabolite | Norclozapine | Normethylclozapine | ACP-104 | ACP104 | ACP 104 | CAS [6104-71-8] | Serotonin; Dopamine | D (Non Selective) | 5-HT (Non Selective) | Agonist | Receptors | Muscarinic M1 | δ Opioid