AS 1842856 is an orally active, potent and selective inhibitor of Forkhead box protein O1 transcription factor (IC50 value of 33 nM). AS 1842856 reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. Therapeutic drug for treating type 2 diabetes.

KEYWORDS: AS 1842856 | supplier | FOXO1 inhibitor | AS1842856 | AS-1842856 | CAS [836620-48-5] | DNA-RNA | FOXO1 | Inhibitor | Transcription Factors | Diabetes | Forkhead box protein O1 transcription factor