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SPT Imidazopyridine 1
Axon 2835
CAS:
1933533-18-6
Purity:
98%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C22H24N2O3
- MW: 364.44
Description
SPT Imidazopyridine 1 is a potent inhibitor of serine palmitoyltransferase (SPT) with an IC50 value of 5 nM. SPT catalyzes the first committed step in de novo sphingolipid synthesis by condensing L-serine with palmitoyl-CoA.
In rodents, SPT Imidazopyridine 1 reduces circulating ceramides and produces changes in lipid handling, including reduced triglycerides and increased HDL in cholesterol/cholic-acid-fed rats. It is used to investigate de novo ceramide biosynthesis, insulin sensitivity and sphingolipid contributions to metabolic disease.
Key Features
- Potent serine palmitoyltransferase inhibitor
- IC50: 5 nM
- Reduces plasma ceramide levels in rodents
- Favorable reported in vitro and ADME profile
Applications
- SPT enzymology
- De novo sphingolipid synthesis research
- Ceramide metabolism studies
- Insulin-sensitivity models
- Dyslipidemia and lipid-homeostasis research
More Information
| Parent CAS No. | 1933533-18-6 |
|---|---|
| Chemical Name | 2-(4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl)acetic acid |
| SMILES | C1(C(=O)CCCCCC)C=C(C2C=CC(CC(=O)O)=CC=2)C2=NC=CN2C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24N2O3/c1-2-3-4-5-6-20(25)18-14-19(22-23-11-12-24(22)15-18)17-9-7-16(8-10-17)13-21(26)27/h7-12,14-15H,2-6,13H2,1H3,(H,26,27) |
| InChiKey | MMYRYMMKMUTPBB-UHFFFAOYSA-N |
| CID | 131954583 |
| Short Description | SPT inhibitor |
SPT Imidazopyridine 1
serine palmitoyltransferase inhibitor
Palmitoyl-CoA
L-serine
SPT
Diabetes
Dyslipidemia
serine palmitoyltransferase
Inhibitor
SPT enzymology
De novo sphingolipid synthesis research
Ceramide metabolism studies
Insulin-sensitivity models
Dyslipidemia and lipid-homeostasis research
metabolism
lipid metabolism
compound synthesis
enzyme pharmacology
drug discovery
CAS 1933533-18-6
Axon Medchem
Axon 2835
Supplier
Vendor
