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Lalistat 2

Axon 2797
CAS:  1234569-09-5
Purity:  99%
  • Soluble in DMSO
  • MF:  C13H20N4O2S
  • MW:  296.39

Description

Lalistat 2 is a potent inhibitor of lysosomal acid lipase (LAL/LIPA) with an IC50 value of 152 nM. It shows little inhibition of human pancreatic lipase or bovine milk lipoprotein lipase at concentrations used in the original selectivity studies.

Lalistat 2 is widely used to distinguish lysosomal acid lipase activity from neutral lipase activity in biochemical and dried-blood-spot assays. It is also used to model impaired lysosomal cholesteryl-ester and triglyceride hydrolysis, although reported effects on neutral lipid metabolism should be considered when interpreting prolonged cellular exposure.

Key Features

  • Potent LAL inhibitor
  • IC50: 152 nM
  • Useful for differential LAL activity assays
  • Limited activity against pancreatic and lipoprotein lipases in initial profiling

Applications

  • LAL and LIPA enzyme assays
  • Dried-blood-spot lipase measurements
  • Lysosomal lipid-metabolism studies
  • Cholesteryl-ester hydrolysis research
  • Lysosomal acid lipase deficiency models

More Information

Parent CAS No. 1234569-09-5
Chemical Name 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
SMILES C1(OC(N2CCCCC2)=O)=NSN=C1N1CCCCC1
MFCD MFCD31544494
InChi InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2
InChiKey PNYYVHOTXOEBEV-UHFFFAOYSA-N
CID 46867138
Short Description LAL inhibitor

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