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Motolimod

 - VTX-2337  - VTX-378
Axon 2783
CAS:  926927-61-9
Purity:  99%
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C28H34N4O2
  • MW:  458.6

Description

Motolimod (VTX-2337) is a potent and selective agonist of Toll-like receptor 8 (TLR8) with an EC50 value of 100 nM. It activates TLR8 signaling in monocytes and myeloid dendritic cells, driving NF-κB-dependent innate immune responses.

Motolimod promotes production of TNF-α, IL-12 and other inflammatory mediators and can indirectly enhance natural-killer-cell activation and IFN-γ release. It is used to study human TLR8 biology, myeloid-cell activation, innate–adaptive immune crosstalk and immunostimulatory combination strategies.

Key Features

  • Potent selective TLR8 agonist
  • EC50: 100 nM
  • Activates monocytes and myeloid dendritic cells
  • Promotes TNF-α, IL-12 and IFN-γ-associated responses

Applications

  • TLR8 signaling research & Innate immune-cell activation
  • Cytokine-release assays
  • Natural-killer-cell studies
  • Cancer immunology and adjuvant research

More Information

Parent CAS No. 926927-61-9
Chemical Name (1E,4E)-2-Amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
SMILES C1C=C(C2C=CC3C=C(C(N(CCC)CCC)=O)CC(N)=NC=3C=2)C=CC=1C(=O)N1CCCC1
MFCD N.A.
InChi InChI=1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-18H,3-6,13-16,19H2,1-2H3,(H2,29,30)
InChiKey QSPOQCXMGPDIHI-UHFFFAOYSA-N
CID 16049404
Short Description TLR8 agonist

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