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STK16-IN-1
Axon 2743
CAS:
1223001-53-3
Purity:
99%
- Soluble in DMSO
- MF: C17H12FN3O
- MW: 293.3
Description
STK16-IN-1 is a selective, ATP-competitive inhibitor of serine/threonine kinase 16 (STK16) with an IC50 value of 295 nM. Kinome profiling indicates a comparatively selective profile, enabling investigation of this understudied membrane-associated kinase.
In MCF-7 cells, STK16-IN-1 reduces cell number and promotes accumulation of binucleated cells, phenotypes that resemble STK16 depletion by RNA interference. It can be used to examine STK16 function in cell division, cytokinesis and proliferation, including combination studies with antiproliferative agents.
Key Features
- Selective ATP-competitive STK16 inhibitor
- IC50: 295 nM
- Produces STK16 knockdown-like cellular phenotypes
- Promotes binucleated-cell accumulation
Applications
- STK16 kinase research
- Cytokinesis and cell-division studies
- Kinase selectivity profiling
- Cell-proliferation assays
- Combination pharmacology studies
More Information
| Parent CAS No. | 1223001-53-3 |
|---|---|
| Chemical Name | 1-(4-Fluoro-3-methylphenyl)-1H-pyrrolo[2,3-h][1,6]naphthyridin-2(7H)-one |
| SMILES | C1(F)C(C)=CC(N2C(=O)C=CC3C=NC4NC=CC=4C2=3)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20) |
| InChiKey | WQNRDXHKVSKUPI-UHFFFAOYSA-N |
| CID | 58525066 |
| Short Description | STK16 inhibitor |
STK16-IN-1
selective ATP-competitive STK16 inhibitor
JWC-029
JWC 029
JWC029
STK16
ATP-competitive STK16
ATP-competitive inhibitor
Inhibitor
STK16 kinase research
Cytokinesis and cell-division studies
Kinase selectivity profiling
Cell-proliferation assays
Combination pharmacology studies
cytokine signaling
kinase signaling
receptor selectivity
drug discovery
enzyme pharmacology
CAS 1223001-53-3
Axon Medchem
Axon 2743
Supplier
Vendor
