Based on 1 reference(s) in Google Scholar 10 10 1

Axon 2675

CAS [902589-96-2]

MF C17H22N4O4S
MW 378.45

  • Purity: 99%
  • Soluble in DMSO



Selective human thymidylate kinase (hTMPK; IC50 value 1.65 µM) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP, and sensitizes cancer cells for low-dose doxorubicin chemotherapy.

Keywords: YMU1 | supplier | TMPK inhibtor | YMU-1 | YMU 1 | CAS [902589-96-2] | Thymidylate pathway | hTMPK | Phosphotransferase | dTTP | dTMP | doxorubicin | tuberculosis | cancer

Size Unit Price Stock
10 mg €110.00 In Stock
50 mg €375.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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