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CXL-1020
- 2-MSPA
Axon 2653
CAS:
950834-06-7
Purity:
99%
- MF: C7H9NO5S2
- MW: 251.28
Description
Nitroxyl (HNO) is a reactive nitrogen species that improves myocardial function by direct positive cAMP-independent lusitropic and inotropic effects and by combined venous and arterial dilation. CXL-1020 is an HNO donor which nonenzymatically decomposes to produce pure HNO. HNO donors are potentially useful for the treatment of heart failure.
More Information
| Parent CAS No. | 950834-06-7 |
|---|---|
| Chemical Name | N-hydroxy-2-(methylsulfonyl)benzenesulfonamide |
| SMILES | C1(S(NO)(=O)=O)=CC=CC=C1S(C)(=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C7H9NO5S2/c1-14(10,11)6-4-2-3-5-7(6)15(12,13)8-9/h2-5,8-9H,1H3 |
| InChiKey | RZRWBKKAFHXNEQ-UHFFFAOYSA-N |
| CID | 52939580 |
| Short Description | HNO donor |
References
- A Arcaro et al. Nitroxyl (HNO) for treatment of acute heart failure. Curr Heart Fail Rep. 2014 Sep;11(3):227-35.
- HN Sabbah et al. Nitroxyl (HNO): A novel approach for the acute treatment of heart failure. Circ Heart Fail. 2013 Nov;6(6):1250-8.
- Diering, S. et al. Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents. J. Biol. Chem. 2020, in press.
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