1-Nitrosocyclohexyl acetate
- NCA
Axon 2603
CAS:
10259-08-2
Purity:
98%
- Soluble in DMSO
- MF: C8H13NO3
- MW: 171.19
Description
1-Nitrosocyclohexyl acetate (NCA) is a potent, long-acting organic nitroxyl (HNO) donor designed for pharmacological research. Unlike standard HNO donors that degrade within minutes, NCA features unique slow-release kinetics that provide sustained delivery of HNO—a chemical relative of nitric oxide (NO) known for its highly favorable and distinct cardiovascular profiles.
As a donor-based pharmacology tool, 1-Nitrosocyclohexyl acetate supports studies linking reactive signaling species to cardiovascular and cellular stress models.
Key Features
- Potent HNO donor
- Extended half-life of approximately 13 hours
- Modulates HNO-dependent signaling or biological activity
- Pharmacological tool for HNO-dependent mechanism studies.
Applications
- HNO pharmacology and target-validation studies
- HNO pathway and signaling assays
- Disease-relevant cellular and translational model systems
- Metabolic pathway and biomarker-response studies
More Information
| Parent CAS No. | 10259-08-2 |
|---|---|
| Chemical Name | 1-nitrosocyclohexyl acetate |
| SMILES | C1(OC(=O)C)(N=O)CCCCC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C8H13NO3/c1-7(10)12-8(9-11)5-3-2-4-6-8/h2-6H2,1H3 |
| InChiKey | GOPUAEYNVWXBPR-UHFFFAOYSA-N |
| CID | 11843278 |
| Short Description | HNO donor |
1-Nitrosocyclohexyl acetate (NCA)
long-acting nitroxyl (HNO) donor
1-Nitrosocyclohexyl acetate
NCA
Cysteine residues
Unclassified
HNO pharmacology
HNO signaling assays
Metabolic pathway and biomarker-response studies
metabolism
cardiovascular research
signal transduction
CAS 10259-08-2
Axon Medchem
Axon 2603
Supplier
Vendor
References
- A El-Armouche et al. The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes. Biochem Biophys Res Commun. 2010;402(2):340–344.
- S Diering et al. Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents. J Biol Chem. 2020 Nov 6;295(45):15342-15365.
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