CBR 5884

Based on 6 reference(s) in Google Scholar 9 10 6

Axon 2585

CAS [681159-27-3]

MF C14H12N2O4S2
MW 336.39

  • Purity: 99%
  • Soluble in DMSO

CBR 5884

Description

Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH; IC50 value 33 µM) with selective toxicity towards cancer cell lines with high serine biosynthetic activity. CBR-5884 shows no inhibitory effect on two other NAD+-dependent dehydrogenases, lactate dehydrogenase (LDH) and MDH1A. A useful tool to study the biology of de novo serine synthesis enabling preclinical evaluation of PHGDH as a target in cancer.

KEYWORDS: CBR 5884 | supplier | PHGDH inhibitor | CBR5884 | CAS [681159-27-3] | 3-phosphoglycerate | PHGDH | dehydrogenase | breast | cancer | serine biosynthesis | NAD+ dependent

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Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €320.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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