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Axon 2581
CAS [1198153-15-9]
MF C14H10Br2N2O3MW 414.05
Inhibitor of the renal urate transporter URAT1 with high selectivity to URAT1 over OAT1 and OAT3 in vitro (Ki values 0.057 µM, 7.2 µM, and 2.4 µM, respectively), capable of increasing the fractional excretion of urinary uric acid, and reducing plasma uric acid more effectively than Benzbromarone. A potential novel therapeutic option with an enhanced pharmacokinetic profile for patients with gout or hyperuricemia.
KEYWORDS: UR 1102 | supplier | URAT1 inhibitor | UR1102 | CAS [1198153-15-9] | Uric acid | URAT | Inhibitor | gout | hyperuricemia | Solute carrier | SLC22A12 | organic anion transporter | OAT | urate | uric acid | Benzbromarone | uricosuric | tophi
(3,5-dibromo-4-hydroxyphenyl)(2H-pyrido[4,3-b][1,4]oxazin-4(3H)-yl)methanone
[1198153-15-9]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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