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UR 1102

 - Epaminurad
Axon 2581
CAS:  1198153-15-9
Purity:  98%
  • Soluble in DMSO
  • MF:  C14H10Br2N2O3
  • MW:  414.05

Description

UR 1102 (Epaminurad) is a inhibitor of the renal urate transporter URAT1 (SLC22A12) inhibitor (Ki = 0.057 µM) with strong selectivity over OAT1 (Ki = 7.2 µM) and OAT3 (Ki = 2.4 µM) in vitro. It effectively increases fractional excretion of urinary uric acid and reduces plasma uric acid more efficiently than Benzbromarone.

Featuring an enhanced pharmacokinetic profile, UR 1102 is a promising therapeutic candidate for gout and hyperuricemia, and an essential tool for URAT1/SLC22A12 mechanistic research.

Key Features

  • Potent URAT1 inhibitor with Ki of 0.057 µM
  • Selective over OAT1 (Ki =7.2 µM) and OAT3 (Ki = 2.4 µM)
  • Modulates URAT1-dependent biological activity (note: URAT1 does not primarily function as a signaling receptor; we can also say transport activity)
  • Supports focused URAT1-mediated transport studies in biochemical and cellular systems

Applications

  • URAT1 pharmacology and target-validation studies
  • URAT1 transport activity studies
  • Disease-model research related to hyperuricemia, gout
  • Transporter or ion-channel functional assays

More Information

Parent CAS No. 1198153-15-9
Chemical Name (3,5-dibromo-4-hydroxyphenyl)(2H-pyrido[4,3-b][1,4]oxazin-4(3H)-yl)methanone
SMILES C(C1=CC(Br)=C(O)C(Br)=C1)(N1CCOC2C=CN=CC=21)=O
MFCD N.A.
InChi InChI=1S/C14H10Br2N2O3/c15-9-5-8(6-10(16)13(9)19)14(20)18-3-4-21-12-1-2-17-7-11(12)18/h1-2,5-7,19H,3-4H2
InChiKey ZMVGQIIOXCGAFV-UHFFFAOYSA-N
CID 44608229
Short Description URAT1 inhibitor

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