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Cardiogenol C hydrochloride
Axon 2550
- Parent CAS: 671225-39-1
Purity:
99%
- Soluble in water and DMSO
- MF: C13H16N4O2.HCl
- MW: 296.75
Description
Selective and efficient inducer of the differentiation of ESCs to cardiomyocytes (EC50 value 0.1 µM for inducing the differentiation of myosin heavy chain (MHC) positive cardiomyocytes from ESCs in P19CL6 cells). Cardiogenol C induces cardiomyogenic function in lineage-committed progenitor cells, and can thus be considered a promising tool to improve cardiac repair by cell therapy.
More Information
| Parent CAS No. | 671225-39-1 |
|---|---|
| Chemical Name | 2-(2-(4-methoxyphenylamino)pyrimidin-4-ylamino)ethanol hydrochloride |
| SMILES | C(O)CNC1C=CN=C(NC2=CC=C(OC)C=C2)N=1.Cl |
| MFCD | MFCD06798334 |
| InChi | InChI=1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H |
| InChiKey | QQAHYSZVJLHCNA-UHFFFAOYSA-N |
| CID | 11345983 |
| Short Description | Stem cell differentiator |
References
- X Wu et al. Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc. 2004 Feb 18;126(6):1590-1.
- AK Mike et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-21.
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