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PF 06447475
Axon 2546
CAS:
1527473-33-1
Purity:
99%
- Soluble in DMSO
- MF: C17H15N5O
- MW: 305.33
Description
PF 06447475 is a potent, selective and brain-penetrant inhibitor of LRRK2 kinase with an IC50 value of 3 nM. It suppresses LRRK2 activity in cellular and in vivo systems and is used to study Parkinson's disease-associated kinase biology.
LRRK2 regulates vesicle trafficking, lysosomal homeostasis, autophagy and neuroinflammatory pathways. PF 06447475 is a useful CNS-active tool for interrogating LRRK2-driven neurodegenerative mechanisms and kinase inhibitor pharmacodynamics.
Key Features
- Brain-penetrant LRRK2 kinase inhibitor
- Reported IC50: 3 nM
- In vivo active and selective LRRK2 pharmacology
- Mitigates neurodegeneration-related phenotypes in reported models
Applications
- LRRK2 and Parkinson's disease research
- CNS kinase inhibitor pharmacology
- Autophagy and lysosomal pathway studies
- Neuroinflammation and neurodegeneration models
More Information
| Parent CAS No. | 1527473-33-1 |
|---|---|
| Chemical Name | 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile |
| extra_info | . |
| SMILES | C(#N)C1=CC=CC(C2C3=C(N4CCOCC4)N=CN=C3NC=2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21) |
| InChiKey | BHTWDJBVZQBRKP-UHFFFAOYSA-N |
| CID | 72706840 |
| Short Description | LRRK2 inhibitor |
PF 06447475
brain-penetrant LRRK2 inhibitor
PF06447475
LRRK2
brain-penetrant LRRK2
dopamine
Inhibitor
LRRK2 and Parkinson's disease research
CNS kinase inhibitor pharmacology
Autophagy and lysosomal pathway studies
Neuroinflammation and neurodegeneration models
autophagy
neuroscience
neuroinflammation
neurodegeneration
Parkinson's research
kinase signaling
receptor selectivity
CNS
CAS 1527473-33-1
Axon Medchem
Axon 2546
Supplier
Vendor
References
- J.L. Henderson et al. Discovery and preclinical profiling of PF-06447475, a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.
- J.P. Daher et al. Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. J Biol Chem. 2015 Aug 7;290(32):19433-44.
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