ARM1 hydrobromide

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2307

CAS [1049743-03-4]

MF C16H14N2S.HBr
MW 347.27

  • Purity: 99%
  • Soluble in DMSO

ARM1 hydrobromide

Description

Novel type of LTA4H inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro.About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate.

KEYWORDS: ARM1 hydrobromide | supplier | LTA4H inhibitor | ARM1 HBr | CAS [1049743-03-4] | [68729-05-5] | Eicosanoid epoxides | LTA4H | Inhibitor | neutrophils | LTA4 | proinflammatory mediator | LTB4 | aminopeptidasePro-Gly-Pro | inflammation

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10 mg €92.00 In Stock
50 mg €300.00 In Stock
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2 x 10 mg €140.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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