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FIPI hydrochloride
Axon 2281
- Parent CAS: 939055-18-2
Purity:
99%
- Soluble in DMSO
- MF: C23H24FN5O2.HCl
- MW: 457.93
Description
Phospholipase D (PLD) inhibitor (IC50 values of 20-25 nM for both PLD1 and PLD2) that rapidly blocks in vivo phosphatidic acid (PA) production with subnanomolar potency.
FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, PIP2 availability, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.
More Information
| Parent CAS No. | 939055-18-2 |
|---|---|
| Chemical Name | 5-fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide hydrochloride |
| SMILES | N1C2=C(C=C(F)C=C2)C=C1C(NCCN1CCC(N2C(=O)NC3=CC=CC=C32)CC1)=O.Cl |
| MFCD | MFCD18382115 |
| InChi | InChI=1S/C23H24FN5O2.ClH/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31;/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31);1H |
| InChiKey | BNMQCDOCYPGJJD-UHFFFAOYSA-N |
| CID | 90488864 |
| Short Description | PLD inhibitor |
References
- W. Su et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol. Pharmacol. 2009, 75, 437-446.
- L. Monovich et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg. Med. Chem. Lett. 2007, 17, 2310-2311.
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